【Midnolin】A Milestone in Protein Degradation within Cells

This article discusses a discovery of protein degradation within eukaryotic cells, focusing on the recently identified protein, Midnolin. Eukaryotic cells employ the proteasome, a macromolecular protease, for the degradation of ubiquitin-tagged proteins. However, the mechanism behind the degradation of proteins lacking ubiquitin modification remains unclear. Researchers have uncovered Midnolin, a nuclear protein that facilitates the selective degradation of transcriptional regulators through the proteasome, even in the absence of ubiquitin tags.